The 49ers edge the Rams 26-23 in OT behind Mac Jones as injuries press SF’s WR corps and Christian McCaffrey anchors a high-volume attack. Kendrick Bourne emerges as a trusted secondary option, while LA’s ball movement is undone by two crucial fumbles and a late fourth-and-1 failure.

Puka Nacua dominates the Rams’ targets; Davante Adams also soaks up heavy looks in a high-volume night. SF’s running game isn’t efficient, but late-down execution and McCaffrey’s versatility keep the 49ers ahead in a tight, PFF-angled showdown.

Week 5 WR rankings pivot on injuries and volatile roles. Pickens benefits from Lamb’s absence in Dallas and is set for more routes on multiple alignments. Bourne could rise for San Francisco with Pearsall/J Jennings sidelined, while Adams remains touchdown-dependent against a stout defense. Brown faces a tough matchup amid trade chatter, and McLaurin’s quad injury clouds Washington’s passing game. Deebo Samuel’s health could unlock SF’s aerial look as Week 5 unfolds.

Top-tier options like Nacua, St. Brown, and Smith-Njigba anchor the early slate, with the rest of the tiered map offering solid upside and obvious risk. Stay tuned for in-week updates, as injury news and late-game hurdles will guide starts, sits, and DFS angles for Week 5.

Thursday Night Football features a high-profile NFC West showdown as the Los Angeles Rams host the San Francisco 49ers. Kyren Williams is the Rams’ likely bellcow, with Christian McCaffrey carrying heavy workload for SF. The top anytime TD picks center Williams (-185) and Davante Adams (+115), with Marquez Valdes-Scantling a long shot (+1300). Purdy (toe) and Pearsall (knee) hover as injury risks that could boost Nacua’s target share in LA. The piece highlights sharp bets and promos across DraftKings, FanDuel, and BetMGM, plus a +4300 parlay to chase big upside.

DraftKings’ new-user promo offers $200 in bonus bets if a first $5 wager wins, with no code required. The Rams visit the 49ers on Thursday Night Football in an NFC West showdown, with LA at -8.5 and a 43.5 total. The preview highlights Brock Purdy’s health, Davante Adams’ status, and the Rams’ weapons—Kyren Williams and Puka Nacua—while spotlighting SF run-game and TD-prop angles for Williams and McCaffrey. Includes promo terms and responsible-gaming notes.